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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1042945Generated: October 30, 2026

Nitric Acid → 1,4-Dinitro-1H-imidazole

https://huagongshe.com/reaction/1042945

Reaction equation

Participants

RoleNameHCIDCharge
ReactantNitric AcidHCID 944—
ReactantAcetic AnhydrideHCID 7918—
ReactantHCID 178526856HCID 178526856—
SolventAcetic AcidHCID 176—
Product1,4-Dinitro-1H-imidazoleHCID 516949669.1%

Reaction Steps

In PATENT DOCUMENT 4, 98 mass % nitric acid is added dropwise to 4-nitroimidazole dissolved in glacial acetic acid and acetic anhydride is further added dropwise thereto to perform nitration reaction, and then the reaction solution is added into crushed ice and 1,4-dinitroimidazole is produced at a yield of 69.1% by performing filtration and drying.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08558005B2
Source datasetuspto-grants-2013_10
ORD IDord-72d91b3ea0134bfb8f86034703053530
Source noteuspto-grants-2013_10