HCID 56926626, compound → HCID 53495647, compound

Participants

Reaction Steps

To a 2-L autoclave, a slurry of compound (V) (n=1, R=Ph, R1=PhO, R2=Me) (100 g, 0.27 mol) in methanol (900 mL) was charged and bubbled with nitrogen for 30 minutes. Then [Rh(COD)(ScRp-DuanPhos)]BF4 (135 mg, 0.2 mmol) was added under nitrogen. The autoclave was then charged hydrogen to 10 bar and stirred at room temperature overnight. The reaction was monitored with HPLC. After the reaction completed, pressure of the hydrogenator was released, and the solution was concentrated to provide the product as oil (100 g). The ee was >99% which was determined by HPLC using Chiralpak AD-H column.

Provenance & Evidence