反应详情

温度

80 °C

To a solution of 2-iodo-1-(methoxy)-4-nitrobenzene (2 g, 7.17 mmol, 1 eq.) and (3,5-dimethylisoxazole)boronic acid (3.03 g, 21.5 mmol, 3 eq.) in DME (44 ml) and water (7 ml) were added tetrakis(triphenylphosphine) palladium(0) (0.415 g, 0.05 eq.) and Ba(OH)2.8H2O (4.52 g, 14.33 mmol, 2 eq.). The mixture was heated at 80° C. for 16 h. To complete the reaction (3,5-dimethylisoxazole)boronic acid (1 eq.) was added and the mixture was heated for 4 h. The cooled mixture was filtered and extracted with DCM. The organic phase was washed with saturated aqueous Sodium hydrogen carbonate and water, dried over Na2SO4 and filtered. Evaporation of the solvent in vacuo gave a crude oil which was precipitated with iPr2O to afford the title compound as a rust solid (1.735 g, 97%). GC/MS m/z: 248

1. additionwas added
2. temperaturethe mixture was heated for 4 h
3. filtrationThe cooled mixture was filtered
4. extractionextracted with DCM
5. washThe organic phase was washed with saturated aqueous Sodium hydrogen carbonate and water
6. dry with materialdried over Na2SO4
7. filtrationfiltered
8. customEvaporation of the solvent in vacuo
9. customgave a crude oil which
10. customwas precipitated with iPr2O