2-tert-Butylaniline → HCID 57465584, compound

Participants

Reaction Steps

A mixture of ethyl 4-chloro-7-(3,5-dimethyl-4-isoxazolyl)-6-(methoxy)-3-quinolinecarboxylate (for a preparation see Intermediate 42 (3.3 g, 9.2 mmol) and 2-tert-butylaniline (2.7 ml, 18.4 mmol) in dioxane (50 ml) was refluxed for 2 days. After cooling, the reaction mixture was evaporated under reduced pressure and the precipitate was purified by chromatography on silica gel eluting with DCM/MeOH (95/5) to give the title compound as a solid (1.2 g, 27.7%).

Provenance & Evidence