HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1043001Generated: October 27, 2026
1-(5-Methyl-1,2-oxazol-3-yl)methanamine → 7-(3,5-Dimethyl-4-isoxazolyl)-4-{[(5-methyl-3-isoxazolyl)methyl]amino}-6-(methyloxy)-3-quinolinecarboxamide
https://huagongshe.com/reaction/1043001
Participants
| Role | Name | HCID | Charge |
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| Reactant | 1-(5-Methyl-1,2-oxazol-3-yl)methanamine | HCID 2776306 | — |
| Reactant | 4-Chloro-7-(3,5-dimethylisoxazol-4-yl)-6-methoxyquinoline-3-carboxamide | HCID 57465581 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | 7-(3,5-Dimethyl-4-isoxazolyl)-4-{[(5-methyl-3-isoxazolyl)methyl]amino}-6-(methyloxy)-3-quinolinecarboxamide | HCID 57465594 | — |
Reaction Steps
A solution of 4-chloro-7-(3,5-dimethyl-4-isoxazolyl)-6-(methyloxy)-3-quinolinecarboxamide (for a preparation see Intermediate 56, 331 mg) and [(5-methyl-3-isoxazolyl)methyl]amine (2.5 eq) in butanol (20 ml) was heated to 110° C. for 4 h. The reaction mixture was evaporated to dryness and hydrolysed with water. The mixture was extracted with DCM and the organic dried over Na2SO4, filtered and concentrated to dryness (280 mg). Used without purification in the subsequent reaction (Example 52).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08557984B2 |
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| Source dataset | uspto-grants-2013_10 |
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| ORD ID | ord-2d581f10179841f9abc9d2d0236c3e52 |
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| Source note | uspto-grants-2013_10 |
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