HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → ethyl 4-fluoro-2-(2-methyl-1H-indol-5-yloxy)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Potassium Phosphate, Tribasic | HCID 62657 | — |
| Reactant | 2-methyl-1H-indol-5-ol | HCID 83336 | — |
| Reactant | Benzoic acid, 2,4-difluoro-, ethyl ester | HCID 2737170 | — |
| Solvent | Diglyme | HCID 8150 | — |
| Product | ethyl 4-fluoro-2-(2-methyl-1H-indol-5-yloxy)benzoate | HCID 67227223 | — |
Reaction Steps
Ethyl 2,4-difluorobenzoate (1.14 g), K3PO4 (1.30 g) and 2-methyl-5-indolol (0.90 g) were stirred at 110° C. in diglyme (12 mL) for 24 hours. The mixture was cooled and poured into ether. The solution was washed three times with 1M NaOH solution, and with brine, and dried. The solution was then concentrated. The concentrate was chromatographed on silica gel with 10% ethyl acetate/hexanes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08557983B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-52fff4b2a65042a4a27cdf32c8efd1c2 |
| Source note | uspto-grants-2013_10 |