HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → HCID 67226237, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 4-(phenylmethoxy)-1H-indole | HCID 88465 | — |
| Reactant | Triisopropylsilyl chloride | HCID 139400 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 67226237 | HCID 67226237 | — |
Reaction Steps
4-Benzyloxyindole (1 g) was treated with 60% oily NaH (135 mg) and triisopropylsilyl chloride (1 g) in THF, purified by flash chromatography (98/2 ethyl acetate/hexanes), then debenzylated in ethanol (35 mL) using Pearlman's catalyst (0.19 g) and a hydrogen balloon.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08557983B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-8b97176937be471dbda475f5d7418ca2 |
| Source note | uspto-grants-2013_10 |