HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1043072Generated: October 27, 2026
4-Chloro-3-nitrobenzenesulfonamide → 4-(1-Isopropylpiperidin-4-ylamino)-3-nitrobenzenesulfonamide
https://huagongshe.com/reaction/1043072
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Chloro-3-nitrobenzenesulfonamide | HCID 7324 | — |
| Reactant | 1-(Propan-2-yl)piperidin-4-amine | HCID 3163333 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-(1-Isopropylpiperidin-4-ylamino)-3-nitrobenzenesulfonamide | HCID 67422519 | — |
Reaction Steps
A suspension of 4-chloro-3-nitrobenzenesulfonamide (1.664 g) triethylamine (2 mL) and 1-isopropylpiperidin-4-amine (1 g) in dioxane (10 mL) was stirred for 16 hours at 90° C. The reaction mixture was cooled to room temperature and the solid material was filtered off. The solid material was washed with 20% methanol/dichloromethane, and the mixture was dried under vacuum, to provide the product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08557983B2 |
|---|
| Source dataset | uspto-grants-2013_10 |
|---|
| ORD ID | ord-23849bd3acc1477fbbc8c236dfddb788 |
|---|
| Source note | uspto-grants-2013_10 |
|---|
