HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1043134Generated: October 26, 2026
Piperazine → Methyl 2-(6-(tert-butoxycarbonylamino)-5-fluoropyridin-3-yloxy)-4-(piperazin-1-yl)benzoate
https://huagongshe.com/reaction/1043134
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Methyl 2-(6-(tert-butoxycarbonylamino)-5-fluoropyridin-3-yloxy)-4-fluorobenzoate | HCID 67226334 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | Methyl 2-(6-(tert-butoxycarbonylamino)-5-fluoropyridin-3-yloxy)-4-(piperazin-1-yl)benzoate | HCID 67226114 | — |
Reaction Steps
Methyl 2-(6-(tert-butoxycarbonylamino)-5-fluoropyridin-3-yloxy)-4-fluorobenzoate (0.170 g) and piperazine (0.154 g) were dissolved in dimethylsulfoxide (2 mL) and heated to 85° C. After 1 hour, the reaction was cooled, poured into dichloromethane (75 mL), and washed with water (30 mL). The organic layer was dried over magnesium sulfate, filtered, and concentrated to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08557983B2 |
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| Source dataset | uspto-grants-2013_10 |
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| ORD ID | ord-1319008446564316b3716b5f25c815bc |
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| Source note | uspto-grants-2013_10 |
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