Morpholine → 4-Morpholinobut-2-YN-1-OL

HRID 1043140Notes

Reaction equation

HRID 1043140 reaction equation
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.Cl[CH2:8][C:9]#[C:10][CH2:11][OH:12]>C1(C)C=CC=CC=1>[O:4]1[CH2:5][CH2:6][N:1]([CH2:8][C:9]#[C:10][CH2:11][OH:12])[CH2:2][CH2:3]1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 2027752-Butyn-1-ol, 4-chloro-

Product 1

HCID 31128494-Morpholinobut-2-YN-1-OL

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent2×

Conditions

Temperature
85 °C

Procedure

To a solution of morpholine (4.36 g) in toluene (15 mL) was added 4-chlorobut-2-yn-1-ol (2.09 g) in toluene (5 mL). The solution was stirred at 85° C. for 3 hours. After cooling, the solid was filtered off. The filtrate was subjected to vacuum distillation to give the title compound.

Workup

  1. temperatureAfter cooling
  2. filtrationthe solid was filtered off
  3. distillationThe filtrate was subjected to vacuum distillation

Sources & evidence

ORD record
ord-042d30d48a3f4cf2baf598c2d3baa1ba
Source dataset
uspto-grants-2013_10
Patent number
US08557983B2

Reaction notes

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