HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → Trifluoroacetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Triethylsilane | HCID 12052 | — |
| Reactant | tert-Butyl ((4,4-difluorocyclohexyl)methyl)carbamate | HCID 57441078 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Diethylether hexane | HCID 21584099 | — |
| Product | Trifluoroacetic acid | HCID 6422 | — |
| Product | (4,4-Difluorocyclohexyl)methanamine | HCID 15604494 | — |
Reaction Steps
A solution of EXAMPLE 396A (3 g) in dichloromethane (35 mL), trifluoroacetic acid (15 mL), and triethylsilane (1 mL) was stirred for 2 hours. The solution was concentrated, then condensed from toluene, and left under high vacuum for 24 hours. The semi-solid was taken up in ether/hexane and filtered to give the title compound as its TFA salt.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08557983B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-367ba7db8c814b7eaeb3e7e39fec29bb |
| Source note | uspto-grants-2013_10 |