HCID 86658267, compound → HCID 46239963, compound

Participants

Reaction Steps

To a solution of crude phosphoramidate 7 in MeOH (2.5 mL) was added 5% Pd on charcoal (40 mg). The atmosphere in the flask was exchanged with hydrogen twice. The mixture was stirred at ambient temperature under one atmosphere of hydrogen for 1 h. The mixture was filtered through a short pad of Celite and the filtrate was concentrated. The crude residue was checked by 1H-NMR and 31P-NMR and ratio of two isomers was ca. 17:1 SP isomer (1) and also matched the SP-isomer by thin layer chromatography. 31P-NMR (DMSO-d6): δ 4.91.

Provenance & Evidence