反应详情

温度

-20 °C

4-hydroxy-4-(4-(trifluoromethoxy)phenyl)piperidine-1-formic acid tert-butyl ester (1.85 g, 5 mmol) was dissolved in dry dichloromethane (30 mL), cooled to −20° C., added dropwise triethyl silicane (696 mg, 6 mmol), added slowly until completed, slowly resumed to stir for 15 h at room temperature. After the reaction was finished, added ice water to quench reaction, partitioned, organic phases were washed by saturated saline, followed by sodium sulphate drying, concentration, column chromatography (PE: EA=20:1) to give 0.6 g light yellow gel-like substance, yield: 34%.

1. additionadded slowly
2. customto quench
3. customreaction
4. custompartitioned
5. washorganic phases were washed by saturated saline
6. concentrationfollowed by sodium sulphate drying, concentration, column chromatography (PE: EA=20:1)
7. customto give 0.6 g light yellow gel-like substance, yield: 34%