反应详情

3-(2-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)ethoxy)propionic acid (377 mg, 1.0 mmol) was dissolved in thionyl chloride, raised the temperature to reflux for 3 h, spun dry, residuals were washed by an appropriate amount of ethyl ether, generated 395 mg target product, yield was 100%, directly put to the next reaction step.

1. temperatureraised the temperature
2. temperatureto reflux for 3 h
3. customspun dry
4. washresiduals were washed by an appropriate amount of ethyl ether
5. customdirectly put to the next reaction step