HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 4-(3-(4-(Trifluoromethoxy)phenoxy)azetidin-1-yl) butyryl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4-(3-(4-(Trifluoromethoxy)phenoxy)azetidin-1-yl)butyric acid | HCID 86685908 | — |
| Product | 4-(3-(4-(Trifluoromethoxy)phenoxy)azetidin-1-yl) butyryl chloride | HCID 86685907 | 97% |
Reaction Steps
4-(3-(4-(trifluoromethoxy)phenoxy)azetidin-1-yl)butyric acid (412 mg, 1.29 mmol) was dissolved in thionyl chloride, raised the temperature to reflux for 3 h, spun dry, residuals were washed by an appropriate amount of ethyl ether, generated 421 mg target product, yield was 97%, directly put to the next reaction step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08563547B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-8b5babe20b4d44be88950e1bfc52c71c |
| Source note | uspto-grants-2013_10 |