HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(3,5-Difluoro-4-(trifluoromethoxy)phenoxy)piperidine → (S)-2-(4-(3,5-difluoro-4-(trifluoromethoxy)phenoxy)piperidin-1-yl)-N-(2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(3,5-Difluoro-4-(trifluoromethoxy)phenoxy)piperidine | HCID 68207006 | — |
| Reactant | (S)-2-chloro-N-(2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)acetamide | HCID 68207026 | — |
| Product | (S)-2-(4-(3,5-difluoro-4-(trifluoromethoxy)phenoxy)piperidin-1-yl)-N-(2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)acetamide | HCID 71577642 | 33.4% |
Reaction Steps
Similar to the manipulation of example 1, with (S)-2-chloro-N-(2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)acetamide (130 mg, 0.50 mmol) and 4-(3,5-difluoro-4-(trifluoromethoxy)phenoxy)piperidine (297 mg, 1.0 mmol) as crude materials, 87 mg title compound was generated and yield was 33%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08563547B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-dcdd93202edb4d20bc025ab358297693 |
| Source note | uspto-grants-2013_10 |