HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-2-chloro-N-(2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)acetamide → (S)-2-(4-(4-(2-methoxyethoxy)phenoxy)piperidin-1-yl)-N-(2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-2-chloro-N-(2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)acetamide | HCID 68207026 | — |
| Reactant | 4-(4-(2-Methoxyethoxy)phenoxy)piperidine | HCID 86685911 | — |
| Product | (S)-2-(4-(4-(2-methoxyethoxy)phenoxy)piperidin-1-yl)-N-(2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)acetamide | HCID 71577644 | 56.4% |
Reaction Steps
Similar to the manipulation of example 1, with (S)-2-chloro-N-(2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)acetamide (130 mg, 0.50 mmol) and 4-(4-(2-methoxyethoxy)phenoxy)piperidine (251 mg, 1.0 mmol) as crude materials, 134 mg title compound was generated and yield was 56%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08563547B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-c33334d65f5943e481a978168ba691fa |
| Source note | uspto-grants-2013_10 |