(S)-2-chloro-N-(2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)acetamide → (S)-2-(4-(4-(2-(cyclopropoxy)ethoxy)phenoxy)piperidin-1-yl)-N-(2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)acetamide

Participants

Role	Name	HCID	Charge
Reactant	(S)-2-chloro-N-(2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)acetamide	HCID 68207026	—
Reactant	4-(4-(2-(Cyclopropoxy)ethoxy)phenoxy)piperidine	HCID 86685915	—
Product	(S)-2-(4-(4-(2-(cyclopropoxy)ethoxy)phenoxy)piperidin-1-yl)-N-(2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)acetamide	HCID 71577724	39%

Reaction Steps

Similar to the manipulation of example 1, with (S)-2-chloro-N-(2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)acetamide (130 mg, 0.50 mmol) and 4-(4-(2-(cyclopropoxy)ethoxy)phenoxy)piperidine (277 mg, 1.0 mmol) as crude materials, 97 mg title compound was generated and yield was 39%.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08563547B2
Source dataset	uspto-grants-2013_10
ORD ID	ord-36a66738a2e8402db136881ff06ea2af
Source note	uspto-grants-2013_10