HCID 23081575, compound → HCID 68207004, compound

HRID 1043549Notes

Reaction equation

HRID 1043549 reaction equation
Cl[CH2:2][C:3]([NH:5][C@@H:6]1[CH2:11][O:10][C:9]2=[N:12][C:13]([N+:15]([O-:17])=[O:16])=[CH:14][N:8]2[CH2:7]1)=[O:4].[F:18][C:19]([F:35])([F:34])[O:20][C:21]1[CH:33]=[CH:32][C:24]([CH2:25][CH:26]2[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]2)=[CH:23][CH:22]=1>>[F:34][C:19]([F:18])([F:35])[O:20][C:21]1[CH:22]=[CH:23][C:24]([CH2:25][CH:26]2[CH2:31][CH2:30][N:29]([CH2:2][C:3]([NH:5][C@@H:6]3[CH2:11][O:10][C:9]4=[N:12][C:13]([N+:15]([O-:17])=[O:16])=[CH:14][N:8]4[CH2:7]3)=[O:4])[CH2:28][CH2:27]2)=[CH:32][CH:33]=1

Participants

3

Reactant 2

HCID 23081575HCID 23081575, compoundHCID 68207026(S)-2-chloro-N-(2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)acetamide

Product 1

HCID 68207004HCID 68207004, compoundYield 62.1%

Procedure

Similar to the manipulation of example 1, with (S)-2-chloro-N-(2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)acetamide (130 mg, 0.50 mmol) and 4-(4-(trifluoromethoxy)benzyl)piperidine (259 mg, 1.0 mmol) as crude materials, 150 mg title compound was generated and yield was 62%.

Sources & evidence

ORD record
ord-99ff49aadab04ccb9724af8ead286c90
Source dataset
uspto-grants-2013_10
Patent number
US08563547B2

Reaction notes

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