HCID 68207020, compound → 2-(2-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)ethoxy)-N-((S)-6,7-dihydro-2-nitro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)acetamide

Participants

Role	Name	HCID	Charge
Reactant	HCID 68207020	HCID 68207020	—
Reactant	(S)-2-chloro-N-(2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)acetamide	HCID 68207026	—
Product	2-(2-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)ethoxy)-N-((S)-6,7-dihydro-2-nitro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)acetamide	HCID 86685917	47.2%

Reaction Steps

Similar to the manipulation of example 1, with (S)-2-chloro-N-(2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)acetamide (130 mg, 0.50 mmol) and 2-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)ethanol (305 mg, 1.0 mmol) as crude materials, 125 mg title compound was generated and yield was 47%.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08563547B2
Source dataset	uspto-grants-2013_10
ORD ID	ord-74770f06fd6a41c6b2489a923b17a860
Source note	uspto-grants-2013_10