HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-amine → 3-(3-(4-(trifluoromethoxy)phenoxy)azetidin-1-yl)-N-((S)-6,7-dihydro-2-nitro-5H-imidazo[2,1-b][1,3]oxazin-6-yl) propanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-amine | HCID 59840621 | — |
| Reactant | 3-(3-(4-(Trifluoromethoxy)phenoxy)azetidin-1-yl)propionyl chloride | HCID 86685903 | — |
| Product | 3-(3-(4-(trifluoromethoxy)phenoxy)azetidin-1-yl)-N-((S)-6,7-dihydro-2-nitro-5H-imidazo[2,1-b][1,3]oxazin-6-yl) propanamide | HCID 71577799 | 32% |
Reaction Steps
Similar to the manipulation of example 22, with (S)-(2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine-6-amine (110 mg, 0.6 mmol) and 3-(3-(4-(trifluoromethoxy)phenoxy)azetidin-1-yl) propionyl chloride (242 mg, 0.72 mmol) as crude materials, title compound as 91 mg yellow powder was generated and yield was 32%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08563547B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-64b5d481a27e4f89ab6d9da92829231e |
| Source note | uspto-grants-2013_10 |