(2-Chloro-4-morpholinopyrido[3,2-d]pyrimidin-6-yl)methanol → (2-(5-fluoro-1H-indol-4-yl)-4-morpholinopyrido[3,2-d]pyrimidin-6-yl)methanol

Participants

Role	Name	HCID	Charge
Reactant	(2-Chloro-4-morpholinopyrido[3,2-d]pyrimidin-6-yl)methanol	HCID 53488008	—
Reactant	1-(tert-Butyldimethylsilyl)-5-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole	HCID 57506725	—
Product	(2-(5-fluoro-1H-indol-4-yl)-4-morpholinopyrido[3,2-d]pyrimidin-6-yl)methanol	HCID 53378054	—

Reaction Steps

(2-Chloro-4-morpholinopyrido[3,2-d]pyrimidin-6-yl)methanol 6 (0.1 g) was reacted with 1-(tert-butyldimethylsilyl)-5-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole via General Procedure A to produce 73.4 mg of 108 following reverse phase HPLC purification. MS (Q1) 380.1 (M)+

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08563540B2
Source dataset	uspto-grants-2013_10
ORD ID	ord-9c15e37b3b9c4ad6b656dea5b64969b3
Source note	uspto-grants-2013_10