戻る
化工社化工社 化学情報印刷レポート · 研究参考用
HRID 1043605作成日：2026年10月25日

Potassium Hydroxide → 2-(1-((2-(1H-indol-3-yl)-4-morpholinopyrido[3,2-d]pyrimidin-6-yl)methyl)piperidin-4-yl)propan-2-ol

https://huagongshe.com/reaction/1043605

反応式

関与物質

役割名称HCID仕込み量
反応物Potassium HydroxideHCID 14797—
反応物1-(phenylsulfonyl)-1H-indol-3-ylboronic acidHCID 2776217—
反応物2-(1-((2-Chloro-4-morpholinopyrido[3,2-d]pyrimidin-6-yl)methyl)piperidin-4-yl)propan-2-olHCID 58404970—
生成物2-(1-((2-(1H-indol-3-yl)-4-morpholinopyrido[3,2-d]pyrimidin-6-yl)methyl)piperidin-4-yl)propan-2-olHCID 53378569—

反応手順

2-(1-((2-chloro-4-morpholinopyrido[3,2-d]pyrimidin-6-yl)methyl)piperidin-4-yl)propan-2-ol from Example 8 (0.1 g) was reacted with 1-(phenylsulfonyl)-3-indoleboronic acid via General Procedure A to yield 56.9 mg 133 following phenylsulfonyl group deprotection with aqueous potassium hydroxide at 50° C. for 2 hours then reverse phase HPLC purification. MS (Q1) 487.3 (M)+

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08563540B2
出典データセットuspto-grants-2013_10
ORD IDord-62ca6f8aa907473aa9416b7db52b3d52
出典メモuspto-grants-2013_10