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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1043607Generated: October 30, 2026

2-Methylindole → HCID 53378675, compound

https://huagongshe.com/reaction/1043607

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-MethylindoleHCID 7224—
ReactantCesium carbonateHCID 10796—
ReactantSodium t-butoxideHCID 23676156—
Reactant2-(1-((2-Chloro-4-morpholinopyrido[3,2-d]pyrimidin-6-yl)methyl)piperidin-4-yl)propan-2-olHCID 58404970—
ProductHCID 53378675HCID 53378675—

Reaction Steps

2-(1-((2-chloro-4-morpholinopyrido[3,2-d]pyrimidin-6-yl)methyl)piperidin-4-yl)propan-2-ol from Example 8 (0.1 g) was reacted with 2-methylindole and sodium-tert-butoxide (instead of cesium carbonate) via General Procedure C to afford 19 mg of 135 following reverse phase HPLC purification. MS (Q1) 501.3 (M)+

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08563540B2
Source datasetuspto-grants-2013_10
ORD IDord-ab5b258d2dc947bd86992b7e665495a8
Source noteuspto-grants-2013_10