Morpholine → 4-((2-Chloro-4-morpholinopyrido[3,2-d]pyrimidin-6-yl)methyl)morpholine

HRID 1043628Notes

Reaction equation

Br[CH2:2][C:3]1[CH:4]=[CH:5][C:6]2[N:7]=[C:8]([Cl:19])[N:9]=[C:10]([N:13]3[CH2:18][CH2:17][O:16][CH2:15][CH2:14]3)[C:11]=2[N:12]=1.[NH:20]1[CH2:25][CH2:24][O:23][CH2:22][CH2:21]1>>[Cl:19][C:8]1[N:9]=[C:10]([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)[C:11]2[N:12]=[C:3]([CH2:2][N:20]3[CH2:25][CH2:24][O:23][CH2:22][CH2:21]3)[CH:4]=[CH:5][C:6]=2[N:7]=1

Participants

Reactant 2

HCID 8083Morpholine

HCID 584049784-(6-(Bromomethyl)-2-chloropyrido[3,2-D]pyrimidin-4-YL)morpholine

Product 1

HCID 584049884-((2-Chloro-4-morpholinopyrido[3,2-d]pyrimidin-6-yl)methyl)morpholine

Procedure

4-(6-(Bromomethyl)-2-chloropyrido[3,2-d]pyrimidin-4-yl)morpholine 7 (0.1 g) was reacted with morpholine via General Procedure B to afford quantitative yield of 4-((2-chloro-4-morpholinopyrido[3,2-d]pyrimidin-6-yl)methyl)morpholine.

Sources & evidence

ORD record: ord-03583d24298f4f7e954617ccd653c5a7
Source dataset: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08563540B2

Reaction notes

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