HRID1043645

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(=O)N1CCC(Cc2ccc3nc(Cl)nc(N4CCOCC4)c3n2)CC1

HCID58404999

未命名化合物

HCID67344275

未命名化合物

PRODUCTS

生成物

结构：CO[C@@H](C)c1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CC3CCN(C(C)=O)CC3)ccc2n1

HCID53379241

未命名化合物

PROCEDURE

实验过程

1-(4-((2-Chloro-4-morpholinopyrido[3,2-d]pyrimidin-6-yl)methyl)piperidin-1-yl)ethanone from Example 148 (0.125 g) was reacted with (S)-2-(1-methoxyethyl)-1H-benzo[d]imidazole via General Procedure D to produce 22.1 mg of 164 following reverse phase HPLC purification. MS (Q1) 530.3 (M)+

WORKUP

后处理

customto produce
custom22.1 mg of 164 following reverse phase HPLC purification

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-84d63dcde62a4c11b0e9f4b834571435
来源数据集: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08563540B2
来源说明: uspto-grants-2013_10

反应 SMILES

Cl[C:2]1[N:3]=[C:4]([N:22]2[CH2:27][CH2:26][O:25][CH2:24][CH2:23]2)[C:5]2[N:11]=[C:10]([CH2:12][CH:13]3[CH2:18][CH2:17][N:16]([C:19](=[O:21])[CH3:20])[CH2:15][CH2:14]3)[CH:9]=[CH:8][C:6]=2[N:7]=1.[CH3:28][O:29][C@H:30]([C:32]1[NH:36][C:35]2[CH:37]=[CH:38][CH:39]=[CH:40][C:34]=2[N:33]=1)[CH3:31]>>[CH3:28][O:29][C@H:30]([C:32]1[N:33]([C:2]2[N:3]=[C:4]([N:22]3[CH2:23][CH2:24][O:25][CH2:26][CH2:27]3)[C:5]3[N:11]=[C:10]([CH2:12][CH:13]4[CH2:18][CH2:17][N:16]([C:19](=[O:21])[CH3:20])[CH2:15][CH2:14]4)[CH:9]=[CH:8][C:6]=3[N:7]=2)[C:34]2[CH:40]=[CH:39][CH:38]=[CH:37][C:35]=2[N:36]=1)[CH3:31]