Hydrazine hydrate (1:1) → 2-Hydrazinyl-4-methylpyridine

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Reaction Steps

In a 25 mL recovery flask, hydrazine hydrate (5 g) was added, and then 2-chloro-4-methylpyridine (1.0 g, 7.84 mmol) was slowly added thereto at room temperature while stirring. After refluxing for three hours, the reaction mixture was cooled and extracted with chloroform twice. The organic phase was washed with saturated brine once and dried over, anhydrous magnesium sulfate. Then, the solvent was distilled off to give 2-hydrazino-4-methylpyridine (crude product).

Provenance & Evidence