Potassium Acetate → HCID 58477157, compound

Participants

Reaction Conditions

Reaction Steps

4.03 g of 3-[3-(5-bromopyrimidin-2-yl)benzyl]-6-(1-methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-a]pyrimidine are suspended in 18 ml of THF, heated to 80° C., and 2.86 g of bis(pinacolato)diboron, 2.65 g of potassium acetate and 126 mg of bis(triphenylphosphine)palladium(II)chloride are added and refluxed at 80° C. for 4 h [RM1]. The hot RM is filtered off with suction, rinsed with THF and evaporated to about 30 ml. 30 ml of water and 1.52 g of sodium perborate are then added and stirred at RT overnight. The mixture is acidified using 1 N HCl, THF is distilled off, the precipitate formed is filtered off with suction, washed with water, sucked dry and dried.

Provenance & Evidence