Dimethyl methylmalonate → HCID 21507539, compound

HRID 1043789Notes

Reaction equation

HRID 1043789 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[C:4]([N:9]2[CH2:14][CH2:13][O:12][CH2:11][CH2:10]2)[N:3]=1.[CH3:15]C(C(OC)=O)C(OC)=O>>[Cl:8][C:6]1[C:7]([CH3:15])=[C:2]([Cl:1])[N:3]=[C:4]([N:9]2[CH2:14][CH2:13][O:12][CH2:11][CH2:10]2)[N:5]=1

Participants

3

Reactant 2

HCID 69104Dimethyl methylmalonateHCID 27720684-(4,6-Dichloropyrimidin-2-yl)morpholine

Product 1

HCID 21507539HCID 21507539, compound

Procedure

4,6-Dichloro-5-methyl-2-morpholinopyrimidine was prepared by similar procedure as 4,6-dichloro-2-morpholinopyrimidine (in Method 22) using dimethyl 2-methylmalonate in place of diethyl malonate. LC/MS (m/z): 248.1 (MH+).

Sources & evidence

ORD record
ord-ad1e8b4f8ac2474ea31b945ae3f77a02
Source dataset
uspto-grants-2013_10
Patent number
US08563549B2

Reaction notes

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