Cesium carbonate → HCID 59507926, compound

Participants

Reaction Conditions

Reaction Steps

The desired compound was prepared as described in Example 2: Pd(OAc)2, BINAP, cesium carbonate, THF (0.8 mL) were mixed with 5-(6-chloro-2-morpholinopyrimidin-4-yl)pyrimidin-2-amine (1 eq.) and 5-methoxyquinolin-3-amine (2 eq), which was prepared as shown in Method 20. The mixture was heated under microwave irradiation for 10 minutes at 110° C. The solution was filtered and concentrated Under reduced pressure. The crude product was purified by preparative reverse phase HPLC. LC/MS (m/z): 431.2 (MH+), Rt 2.03 minutes.

Provenance & Evidence