HCID 59507518, compound → HCID 23630334, compound

Participants

Reaction Steps

tert-butyl 4-(6-(2,4-diaminopyrimidin-5-yl)-2-morpholinopyrimidin-4-yloxy)piperidine-1-carboxylate was prepared by Suzuki reaction tert-butyl 4-(6-chloro-2-morpholinopyrimidin-4-yloxy)piperidine-1-carboxylate, as shown in Step 2 of Example 19, with 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine-2,4-diamine (prepared as in Method 7). The crude product was purified by reverse phase HPLC and isolated as the free base after extraction into EtOAc upon basifying (70%). LCMS (m/z): 473.1 (MH+). The title compound was prepared by cleaving the N-Boc protecting group as shown in Step 3 of Example 19. LCMS (m/z): 373.0 (MH+).

Provenance & Evidence