反应详情

Bis(dibenzylidineacetone)palladium (15 mg, 0.026 mmol) and (2′-dicyclohexyl phosphanyl-biphenyl-2-yl)-dimethylamine (40 mg, 0.1 mmol) were added to dry toluene (5 mL purged with argon for 30 min), and the mixture was stirred for an additional 30 minutes at room temperature under argon. Potassium tert-butoxide (188 g, 71 mmol), compound 7 (191 mg, 0.8 mmol), aid compound 8 (200 mg, 0.67 mmol) were then added; the reaction mixture was stirred at 80° C. overnight. The reaction mixture was then cooled to room temperature, filtered through a pad of silica gel, and purified by preparative TLC (DCM/MeOH 5%) to afford compound 11.

1. stirringthe reaction mixture was stirred at 80° C. overnight
2. temperatureThe reaction mixture was then cooled to room temperature
3. filtrationfiltered through a pad of silica gel
4. custompurified by preparative TLC (DCM/MeOH 5%)