tert-Butyl carbazate → HCID 72309493, compound

HRID 1043876Notes

Reaction equation

HRID 1043876 reaction equation
O=[C:2]1[CH2:6][CH2:5][O:4][CH2:3]1.[C:7]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])(=[O:10])[NH:8][NH2:9]>CO>[O:4]1[CH2:5][CH2:6][C:2](=[N:9][NH:8][C:7]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH2:3]1

Participants

4

Reactant 2

HCID 70091tert-Butyl carbazateHCID 5293923-Oxotetrahydrofuran

Product 1

HCID 72309493HCID 72309493, compoundYield 113.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

3-oxotetrahydrofuran (10.38 g) was dissolved in methanol (200 mL), and t-butyl carbazate (17.53 g) was added to the solution. The mixture was stirred at room temperature for 12 hours. The reaction mixture was concentrated to give the title compound (27.3 g). 1H-NMR (400 MHz, CDCl3) δ (ppm): 1.52 (s, 9H), 2.46 (t, J=6.9 Hz, al), 4.10 (t, J=6.9 Hz, 2H), 4.33 (s, 2H).

Workup

  1. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-23a8f39bfbf64426b5f81b0a33ecfbdb
Source dataset
uspto-grants-2013_10
Patent number
US08563565B2

Reaction notes

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