Chlorosuccinimide → 3-Bromo-5-chloro-6-methoxy-2,4-dimethylpyridine

Participants

Reaction Conditions

Reaction Steps

3-bromo-6-methoxy-2,4-dimethylpyridine obtained in Preparation Example 22 (800 mg) was added to DMF (4 mL). NCS (494 mg) was added to the solution, and the mixture was stirred at 80° C. for 14 hours. The reaction mixture was concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (ethyl acetate/n-heptane, 5% to 30%). The title compound (930 mg) was obtained.

Provenance & Evidence