Tetrabutylammonium Fluoride → 3-Bromo-2-(fluoromethyl)-6-methoxy-4-methylpyridine

Participants

Reaction Steps

A mixture of 3-bromo-2-(bromomethyl)-6-methoxy-4-methylpyridine (126 mg) and TBAF (1.71 mL, 1 M solution in THF) was stirred at room temperature for two hours. The reaction mixture was concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography (ethyl acetate/n-heptane, 0% to 10%) to give the title compound (37 mg).

Provenance & Evidence