反应详情

A mixture of (2-methoxy-6-methylpyridin-4-yl)methanol (1.1 g) and NBS (1.34 g) was stirred in an acetic acid solvent (22 mL) at room temperature for 12 hours. A 5 M aqueous sodium hydroxide solution was added to the reaction mixture, followed by extraction with ethyl acetate. The organic layer was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/n-heptane, 10% to 50%) to give the title compound (1.32 g).

1. extractionfollowed by extraction with ethyl acetate
2. concentrationThe organic layer was concentrated under reduced pressure
3. customthe residue was purified by silica gel column chromatography (ethyl acetate/n-heptane, 10% to 50%)