Tetrafluoroboric acid → 3-Bromo-6-fluoro-2,4-dimethylpyridine

Temperature

0 °C

2-amino-5-bromo-4,6-dimethylpyridine (2 g) was suspended in fluoroboric acid (48% aqueous solution, 7.5 mL). Sodium nitrite (890 mg) dissolved in water (3 mL) was added to the solution at 0° C. The reaction mixture was stirred at 0° C. for 10 minutes. The precipitated solid was collected by filtration and suspended in n-heptane (100 mL). The solution was stirred with heating under reflux for two hours. After cooling to room temperature, the precipitated solid was collected by filtration. The resulting solid was dried under reduced pressure to give the title compound (500 mg).

1. additionwas added to the solution at 0° C
2. filtrationThe precipitated solid was collected by filtration
3. stirringThe solution was stirred
4. temperaturewith heating
5. temperatureunder reflux for two hours
6. temperatureAfter cooling to room temperature
7. filtrationthe precipitated solid was collected by filtration
8. customThe resulting solid was dried under reduced pressure

ORD record

ord-e59142eaa1af4fccb70993bcebb01828

Source dataset

uspto-grants-2013_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08563565B2