HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Sulfate → 2-(Difluoromethoxy)-4-iodo-3,5-dimethylpyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Sulfate | HCID 24436 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 2,2-Difluoro-2-(fluorosulfonyl)acetic acid | HCID 2737516 | — |
| Reactant | HCID 178430689 | HCID 178430689 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 2-(Difluoromethoxy)-4-iodo-3,5-dimethylpyridine | HCID 86686348 | — |
Reaction Steps
4-iodo-3,5-dimethylpyridin-2-ol (350 mg), 2-(fluorosulfonyl)difluoroacetic acid (0.17 mL), and sodium sulfate (39.9 mg) were added to acetonitrile (5.7 mL). The mixture was stirred at room temperature for 3.5 hours. A saturated aqueous sodium bicarbonate solution was added to the reaction mixture, followed by extraction with ethyl acetate. The organic layer was concentrated under reduced pressure to give the title compound (378.6 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08563565B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-0e4a0e757bd349caa303e4b7767e4772 |
| Source note | uspto-grants-2013_10 |