反应详情

温度

100 °C

To a solution of α-bromophenylacetic acid (1.00 g, 4.65 mmol) in acetonitrile (20 ml), was added 4-chloro-phenylamine (1.18 g, 9.30 mmol), and the mixture was heated under microwave irradiation at 100° C. for 1 hour (UPLC-MS monitoring: complete conversion). The solvent was evaporated, and the residue was positioned between EtOAc and 1N HCl. The organic phase was dried over Na2SO4, filtered and evaporated to dryness to obtain intermediate I11 (0.57 g; 47% yield).

1. customThe solvent was evaporated
2. dry with materialThe organic phase was dried over Na2SO4
3. filtrationfiltered
4. customevaporated to dryness
5. customto obtain intermediate I11 (0.57 g; 47% yield)