HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → 4-Amino-3-methoxy-n-(1-methylpiperidin-4-yl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2486-69-3 | HCID 288057 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 4-Amino-1-methylpiperidine | HCID 2737531 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-Amino-3-methoxy-n-(1-methylpiperidin-4-yl)benzamide | HCID 11529063 | — |
Reaction Steps
To 4-amino-3-methoxybenzoic acid (1.064 g mg, 6.37 mmol) in dichloromethane (50 ml) was added DIPEA (2.22 ul, 12.74 mmol) and TBTU (2.25 g, 7.0 mmol) and the mixture stirred for 10 minutes. 4-amino-1-methylpiperidine (0.872 g, 7.65 mmol) was added and stirring continued for 16 hours. The resulting solid was filtered and dried under vacuum (1.04 g, 3.95 mmol, 62%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08563542B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-9c3794379faa4788835d740d655cb513 |
| Source note | uspto-grants-2013_10 |