HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Chloride → 2'-chloro-9'-cyclopentyl-8',9'-dihydrospiro[cyclobutane-1,7'-pyrimido[4,5-b][1, 4]diazepin]-6'(5'H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | 1-{[(2-Chloro-5-nitro-pyrimidin-4-yl)-cyclopentyl-amino]-methyl}-cyclobutanecarboxylic acid methyl ester | HCID 58153885 | — |
| Catalyst | Iron | HCID 23925 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2'-chloro-9'-cyclopentyl-8',9'-dihydrospiro[cyclobutane-1,7'-pyrimido[4,5-b][1, 4]diazepin]-6'(5'H)-one | HCID 57970008 | — |
Reaction Steps
Reaction of 1-{[(2-chloro-5-nitro-pyrimidin-4-yl)-cyclopentyl-amino]-methyl}-cyclobutanecarboxylic acid methyl ester with NH4Cl and iron powder in ethanol gave 2′-chloro-9′-cyclopentyl-8′,9′-dihydrospiro[cyclobutane-1,7′-pyrimido[4,5-b][1,4]diazepin]-6′(5′H)-one, isolated directly.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08563542B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-60a48ba26416438ba5d08a206c6775a4 |
| Source note | uspto-grants-2013_10 |