HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → Methyl 2-fluoro-4-(trifluoromethyl)nicotinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Fluoro-4-(trifluoromethyl)pyridine-3-carboxylic acid | HCID 28307766 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Methyl 2-fluoro-4-(trifluoromethyl)nicotinate | HCID 58577652 | 99.9% |
Reaction Steps
To a mixture of 2-fluoro-4-(trifluoromethyl)pyridine-3-carboxylic acid (1.06 g) and K2CO3 (0.701 g) in DMF (dry) (10 mL) was added MeI (0.317 mL). The mixture was stirred at room temperature for 3 h. The mixture was directly purified by column chromatography (silica gel, EtOAc/hexane) to give the title compound (1.13 g, containing EtOAc and hexane, ca. 75% purity).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08563575B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-575d1603779542e797fe83b930b0aa29 |
| Source note | uspto-grants-2013_10 |