反应详情

温度

60 °C

To a mixture of methyl 2-{[4-(benzyloxy)phenyl]amino}-4-(trifluoromethyl)pyridine-3-carboxylate (255 mg) in MeOH (5 mL) was added 1N NaOH (2.54 mL), and the mixture was stirred at 60° C. for 3 h. After MeOH was evaporated, to the water phase was added 1N HCl (pH=ca. 2). The precipitate was collected by filtration to give the title compound (221 mg).

1. customAfter MeOH was evaporated, to the water phase
2. additionwas added 1N HCl (pH=ca. 2)
3. filtrationThe precipitate was collected by filtration