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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1044323Generated: November 1, 2026

Phenethylamine → 3-(p-Tolyl)-1,4-dihydro-4-oxo-5-phenethylamino-1,6-naphthyridine

https://huagongshe.com/reaction/1044323

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPhenethylamineHCID 1001—
Reactant4-ChloroanilineHCID 7812—
ReactantEthyl (4-chlorophenyl)acetateHCID 84177—
ReactantEthyl (4-(trifluoromethyl)phenyl)acetateHCID 14134124—
Reactant3-(4-Trifluoromethylphenyl)-1,4-dihydro-4-oxo-5-(4-chlorophenylamino)-1,6-naphthyridineHCID 46847805—
Product3-(p-Tolyl)-1,4-dihydro-4-oxo-5-phenethylamino-1,6-naphthyridineHCID 46847609—

Reaction Steps

3-(4-Trifluoromethylphenyl)-1,4-dihydro-4-oxo-5-(4-chlorophenylamino)-1,6-naphthyridine The title compound was prepared as described in Example 1 above except that ethyl (4-chlorophenyl)acetate was replaced with ethyl (4-trifluoromethyl-phenyl)acetate and phenethylamine was replaced with 4-chloroaniline. MS 416 (M+1)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08563579B2
Source datasetuspto-grants-2013_10
ORD IDord-0c818d7e4a9949b59602ec8d2c717033
Source noteuspto-grants-2013_10