Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | 15-Crown-5 | HCID 36336 | — |
| Reactant | 2-[4-(Bromomethyl)phenyl]propanoic acid | HCID 2733978 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 86658306 | HCID 86658306 | — |
Reaction Steps
To a solution of 2-(4-bromomethylphenyl)-proprionic acid (1.5 g) in 1,4-dioxane was added NaN3 (5 g) and 15-crown-5 (100 mg). The mixture was heated to 80° C. for 16 h, then cooled. The solvent was removed under reduced pressure, and the residue chromatographed on silica to yield 2-(4-azidomethylphenyl)-proprionic acid as an off white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08563585B2 |
|---|
| Source dataset | uspto-grants-2013_10 |
|---|
| ORD ID | ord-c39460d71aac4d90b457660fc0a92646 |
|---|
| Source note | uspto-grants-2013_10 |
|---|
