Methanol → HCID 178507692, compound

HRID 1044349Notes

Reaction equation

HRID 1044349 reaction equation
[OH:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([N:8]2[CH2:12][CH2:11][C:10]3([CH2:17][CH2:16][CH2:15][N:14]([C:18]4[CH:23]=[CH:22][C:21]([N+:24]([O-])=O)=[CH:20][CH:19]=4)[CH2:13]3)[C:9]2=[O:27])[CH2:4][CH2:3]1.CO>[Pd]>[NH2:24][C:21]1[CH:22]=[CH:23][C:18]([N:14]2[CH2:15][CH2:16][CH2:17][C:10]3([C:9](=[O:27])[N:8]([C@H:5]4[CH2:4][CH2:3][C@H:2]([OH:1])[CH2:7][CH2:6]4)[CH2:12][CH2:11]3)[CH2:13]2)=[CH:19][CH:20]=1

Participants

4

Reactant 2

HCID 887MethanolHCID 178517860HCID 178517860, compound

Product 1

HCID 178507692HCID 178507692, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

A mixture of 2-(trans-4-hydroxycyclohexyl)-7-(4-nitrophenyl)-2,7-diazaspiro[4.5]decan-1-one (0.13 g, 0.00028 mol, prepared by using a procedure that was analogous to that described for the synthesis of example 43), 10% Pd/C (activated) in methanol (5 mL, 0.1 mol) was stirred under a H2 atmosphere (balloon) for 1.5 hour. The catalyst was filtered and the filtrate was concentrated in-vacuo to afford the desired product in quantitative yield. LC-MS: 344.3 (M+H)+.

Workup

  1. customprepared
  2. filtrationThe catalyst was filtered
  3. concentrationthe filtrate was concentrated in-vacuo

Sources & evidence

ORD record
ord-0f01c75bc59e46fc8bd51bd34ccb78a6
Source dataset
uspto-grants-2013_10
Patent number
US08563570B2

Reaction notes

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