HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiophenol → S-Phenyl 2-(4-methoxyphenyl)ethanethioate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thiophenol | HCID 7969 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-Methoxyphenylacetyl chloride | HCID 2734688 | — |
| Reactant | Isohexane ethyl acetate | HCID 21882781 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | S-Phenyl 2-(4-methoxyphenyl)ethanethioate | HCID 15576549 | 97% |
Reaction Steps
2-(4-Methoxyphenyl)acetyl chloride (3.06 mL, 20.0 mmol) in 60 mL toluene was added to a solution of triethylamine (2.80 mL, 20.1 mmol) and thiophenol (2.04 mL, 20.0 mmol) in 40 mL toluene. Reaction monitoring was accomplished by TLC: iso-hexane/ethyl acetate 25:1, Rf=0.29. Workup yielded 4.99 g (97%) S-phenyl 2-(4-methoxyphenyl)ethanethioate 3 as crystalline yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08563598B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-7328bc729cb249bb8e3306ef30421406 |
| Source note | uspto-grants-2013_10 |