HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiophenol → Hexanethioic acid, S-phenyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thiophenol | HCID 7969 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Hexanoyl chloride | HCID 67340 | — |
| Reactant | Isohexane ethyl acetate | HCID 21882781 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Hexanethioic acid, S-phenyl ester | HCID 11195139 | 95% |
Reaction Steps
Hexanoyl chloride (2.76 mL, 19.7 mmol) in 60 mL toluene was added to a solution of triethylamine (2.80 mL, 20.1 mmol) and thiophenol (2.04 mL, 20.0 mmol) in 40 mL toluene. Reaction monitoring was accomplished by TLC: iso-hexane/ethyl acetate 100:1, Rf=0.20. Workup yielded 3.89 g (95%) S-phenyl hexanethioate 4 as pale yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08563598B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-94737f12d40e4da1aac75781c3861691 |
| Source note | uspto-grants-2013_10 |