反应详情

A mixture of acetic acid 2-[cyclopropyl-(propane-1-sulfonyl)-amino]ethyl ester (1.7 g, 6.8 mmol) and KOH (0.57 g, 10.2 mmol) in 30 ml Methanol was stirred over night at room temperature. The solvent was evaporated the residue dissolved in ethyl acetate and subsequently extracted with water and 1 M KOH, dried over Na2SO4 and the solvent evaporated to obtain 0.46 g of product which was used purified by chromatography (253.5 mg of colorless oil)

1. customThe solvent was evaporated the residue
2. dissolutiondissolved in ethyl acetate
3. extractionsubsequently extracted with water and 1 M KOH
4. dry with materialdried over Na2SO4
5. customthe solvent evaporated