HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperazine → 1-[4-(Trifluoromethyl)pyridin-2-yl]piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Chloro-4-(trifluoromethyl)pyridine | HCID 144958 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-[4-(Trifluoromethyl)pyridin-2-yl]piperazine | HCID 11218492 | 43% |
Reaction Steps
A solution of 2-chloro-4-(trifluoromethyl)pyridine (2.0 g, 11 mmol), piperazine (3 g, 30 mmol) and triethylamine (3.1 mL, 22 mmol) in DMF (10 mL) was heated at 100° C. overnight and concentrated in vacuo. The residue was purified by column chromatography on silica gel (EtOAc to EtOAc/MeOH/Et3N=9/1/0.5) to give 1.09 g (43%) of pure product MS calculated for C10H12F3N3: (M+H) 232; found 232.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08563582B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-5166e58b18fe44458bb8f26491c5311d |
| Source note | uspto-grants-2013_10 |